Harris, playing his final home game for Wake Forest, went 8 of 14 from the field, including a perfect 6 of 6 on 3-pointers, and 7 of 9 on the free throw line to equal his career high, set two months ago against Boston College.
Green was 9 of 18 from the field, including three 3-pointers, and 14 of 18 from the line to tie his career best, set Jan. 24 against Virginia.
Ahead 41-27 at the half, the Demon Deacons pushed their lead past the 20-point mark early in the second half.
Wake Forest took its biggest lead with less than eight minutes remaining, going up 80-56 on Thomas' layup with 7:57 remaining.
The Demon Deacons dominated the first half, shooting 60.9 percent (14 of 23) from the field, including 5 of 9 on 3-pointers, and hitting 8 of 12 free throws. They also outrebounded the Hokies 17-14 and led by as many as 16 points.
Harris hit four 3-pointers to score 12 points in the first half.
The Demon Deacons opened with a 9-0 run in the first 2 1/2 minutes and built their first double-digit lead by the 16-minute mark behind Moto (11 points) and Thomas (10 points).
Wake Forest took its biggest lead of the half, 38-22, on
Virginia Tech then made its closest run since the opening minutes, with Eddie's 3-pointer and a Green runner pulling the Hokies within 38-27 with 1:31 left. But Thomas' layup and a Miller-McIntyre free throw put Wake Forest up 41-27 at the end of the half.